Understanding Clearance and Plasma Timelines
Whether for planning your daily routine or understanding clearance intervals, questions regarding 7-OH half life are among the most common inquiries our scientific team receives.
Elimination Half-Life Explained
Pharmacokinetic studies indicate that 7-hydroxymitragynine exhibits a terminal elimination half-life (t1/2) of approximately 2.5 to 3.5 hours in healthy adults. This means that every 3 hours, your body metabolizes and eliminates roughly 50% of the circulating alkaloid concentration.
Timeline from Ingestion to Complete Clearance
- 15–45 Minutes: Absorption phase and onset of peak plasma concentration (Cmax).
- 4–6 Hours: Active pharmacological duration for physical ease and relaxation.
- 18–24 Hours: Over 95% of active metabolites are cleared via renal and biliary excretion pathways.
For more details on responsible daily intervals, see our FAQ Dosing Guide or browse our Product Selection.